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胡志刚

胡志刚 博士

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工作学习经历:

2014年1月至今,澳门新葡亰平台官网生命科学官网 副教授

2010年1月至2013年11月,斯坦福大学医官网博士后

2007年2月至2009年,韩国东亚大学自然资源与生命科学官网,理学博士学位

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研究方向:

1、代谢性疾病研究

2、DNA损伤修复与肿瘤发生研究

3、CAR-T等肿瘤免疫治疗

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主持项目:

1、GIPC1/SR-B1调节体内胆固醇平衡和脂代谢研究,2019.7-2022.6,江苏省教育厅重点项目

2、高密度脂蛋白受体(SR-BI)的泛素化修饰及功能研究,2015.01-2017.12,国家自然科学基金青年项目

3、高密度脂蛋白受体(SR-BI)蛋白质翻译后修饰及功能研究,2014.07-2017.06,江苏省自然科学基金青年项目

4、高密度脂蛋白磷酸化修饰及功能研究,2014.08-2016.12,江苏省高校自然科学研究面上项目

5、miR-24对高密度脂蛋白受体(SR-BI)的表达调控及机制研究,教育部留学回国人员科研项目启动基金

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学术兼职:

江苏省生理科学学会秘书长;美国生理学会会员;中国生物化学与分子生物学学会会员,江苏省生物化学与分子生物学青年委员会委员;Oncology letters, Gene, Frontier in endocrinology, Acta Biochimica et Biophysica Sinica等期刊审稿人;教育部学位与研究生教育发展中心学位论文评审专家。

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Email: huzg_2000AT126.com(发邮件时请将AT换成@)

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代表性论著(*通讯作者):

  1. Li L, Kumar AK, Hu Z*, Guo Z*.Small Molecule Inhibitors Targeting the Key Proteins in DNA Damage Response for Cancer Therapy.Curr Med Chem. 2020, 27: 1.
  2. Liu R, Wang M, Li E, Yang Y, Li J, Chen S, Shen WJ, Azhar S, Guo Z, Hu Z*.Dysregulation of microRNA-125a contributes to obesity-associated insulin resistance and dysregulates lipid metabolism in mice.Biochim Biophys Acta-Mol Cell Biol Lipids. 2020 May;1865(5):158640.
  3. Lu X, Liu R, Wang M, Kumar AK, Pan F, He L, Hu Z*, Guo Z*.MicroRNA-140 impedes DNA repair by targeting FEN1 and enhances chemotherapeutic response in breast cancer.Oncogene. 2020 Jan;39(1):234-247.
  4. Wang M, Li E, Lin L, Kumar AK, Pan F, He L, Zhang J, Hu Z*, Guo Z*.Enhanced Activity of Variant DNA Polymerase β (D160G) Contributes to Cisplatin Therapy by Impeding the Efficiency of NER.Mol Cancer Res. 2019 Oct;17(10):2077-2088. (Highlights paper)
  5. Hu Z, Hu J, Zhang Z, Shen WJ, Yun CC, Berlot CH, Kraemer FB, Azhar S*.Regulation of expression and function of scavenger receptor class B, type I (SR-BI) by Na+/H+ exchanger regulatory factors (NHERFs).J Biol Chem. 2013 Apr 19;288(16):11416-35.
  6. Hu Z, Shen WJ, Kraemer FB, Azhar S*.MicroRNAs 125a and 455 repress lipoprotein-supported steroidogenesis by targeting scavenger receptor class B type I in steroidogenic cells.Mol Cell Biol. 2012 Dec;32(24):5035-45.

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其他论文(*通讯作者):

  1. Azhar S, Dong D, Shen WJ, Hu Z, Kraemer FB. The role of miRNAs in regulating adrenal/gonadal steroidogenesis. J Mol Endocrinol. 2020 Jan;64(1):R21-R43.
  2. Zhu H, Wu C, Wu T, Xia W, Ci S, He W, Zhang Y, Li L, Zhou S, Zhang J, Edick AM, Zhang A, Pan FY, Hu Z, He L, Guo Z. Inhibition of AKT Sensitizes Cancer Cells to Antineoplastic Drugs by Downregulating Flap Endonuclease 1.Mol Cancer Ther. 2019 Dec;18(12):2407-2420.
  3. Xia W, Ci S, Li M, Wang M, Dianov GL, Ma Z, Li L, Hua K, Alagamuthu KK, Qing L, Luo L, Edick AM, Liu L, Hu Z, He L, Pan F, Guo Z. Two-way crosstalk between BER and c-NHEJ repair pathway is mediated by Pol-β and Ku70.FASEB J. 2019 Nov;33(11):11668-11681.
  4. He L, Zhu H, Zhou S, Wu T, Wu H, Yang H, Mao H, SekharKathera C, Janardhan A, Edick AM, Zhang A, Hu Z, Pan F, Guo Z. Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells.Exp Mol Med. 2018 Aug 14;50(8):101.
  5. Wang M, Li L, Liu R, Song Y, Zhang X, Niu W, Kumar AK, Guo Z, Hu Z*.Obesity-induced overexpression of miRNA-24 regulates cholesterol uptake and lipid metabolism by targeting SR-B1.Gene. 2018 May 19. (18)30569-9.
  6. He L, Yang H, Zhou S, Zhu H, Mao H, Ma Z, Wu T, Kumar AK, Kathera C, Janardhan A, Pan F, Hu Z, Yang Y, Luo L, Guo Z. Synergistic antitumor effect of combined paclitaxel with FEN1 inhibitor in cervical cancer cells. DNA Repair. 2018 Mar;63:1-9.
  7. He L, Luo L, Zhu H, Yang H, Zhang Y, Wu H, Sun H, Jiang F, Kathera CS, Liu L, Zhuang Z, Chen H, Pan F, Hu Z, Zhang J, Guo Z.. FEN1 promotes tumor progression and confers cisplatin resistance in non‐small cell lung cancer[J]. Molecular Oncology, 201711(9):1302-1303.
  8. Hu Z, Shen WJ, et al. Regulation of adrenal and ovarian steroidogenesis by miR-132.[J]. Journal of Molecular Endocrinology, 2017, 59(3):269-283.
  9. Lu X, He L, Zhou Q, Wang M, Shen WJ, Azhar S, Pan F, Guo Z, Hu Z*. NHERF1 and NHERF2 regulation of SR-B1 stability via ubiquitination and proteasome degradation.[J]. Biochemical & Biophysical Research Communications, 2017490(4): 1168-1175.
  10. Li J, Zhou Q, Ma Z, Wang M, Shen WJ, Azhar S, Guo Z, Hu Z*. Feedback inhibition of CREB signaling by p38 MAPK contributes to the negative regulation of steroidogenesis[J]. Reproductive Biology and Endocrinology, 2017, 15(1): 19.
  11. Sun, H., He, L., Wu, H., Pan, F., Wu, X., Zhao, J., Hu, Z., Sekhar, C., Li, H., Zheng, L., Chen, H., Shen, B. H. and Guo, Z. (2017) The FEN1 L209P mutation interferes with long-patch base excision repair and induces cellular transformation. Oncogene. 36, 194-207.
  12. Pan F, Zhao J, Zhou T, Kuang Z, Dai H, Wu H, Sun H, Zhou X, Wu X, Hu Z, He L, Shen B, Guo Z. Mutation of DNA Polymerase β R137Q Results in Retarded Embryo Development Due to Impaired DNA Base Excision Repair in Mice. Sci Rep. 2016, 6:28614.
  13. Hu Z*, Li J, Kuang Z, et al. Cell-Specific Polymorphism and Hormonal Regulation of DNA Methylation in Scavenger Receptor Class B, Type I[J]. DNA and cell biology, 2016, 35(6): 280-289.
  14. Zhou X, Zhuang Z, Wang W, He L, Wu H, Cao Y, Pan F, Zhao J, Hu Z, Sekhar C, Guo Z. OGG1 is essential in oxidative stress induced DNA demethylation. Cell Signal. 2016, 28(9):1163-1171.
  15. Shen W J, Hu Z, Hu J, et al. Post-transcriptional and Post-translational Regulation of Steroidogenesis[M]//Post-transcriptional Mechanisms in Endocrine Regulation. Springer International Publishing, 2016: 253-275.
  16. Zhou T, Pan F, Cao Y, Han Y, Zhao J, Sun H, Zhou X, Wu X, He L, Hu Z, Chen H, Shen B, Guo Z.. R152C DNA Pol β mutation impairs base excision repair and induces cellular transformation. Oncotarget, 2016, 7(6): 6902.
  17. Hu Z, Hu J, Shen W J, et al. A Novel Role of Salt-Inducible Kinase 1 (SIK1) in the Post-Translational Regulation of Scavenger Receptor Class B Type 1 Activity. Biochemistry, 2015, 54(46):6917-30.
  18. Cao Y, .. Hu Z.., Guo Z. Selection and characterization of human PCSK9 antibody from phage displayed antibody library[J]. Biochemical and biophysical research communications, 2015, 463(4): 712-718.
  19. Shen W J, Hu J, Hu Z, et al. Scavenger receptor class B type I (SR-BI): a versatile receptor with multiple functions and actions[J]. Metabolism, 2014, 63(7): 875-886.
  20. Hu Z, Shen W J, Cortez Y, et al. Hormonal regulation of microRNA expression in steroid producing cells of the ovary, testis and adrenal gland[J]. PloS one, 2013, 8(10): e78040-e78040.
  21. Hu Z., Lee K.S., et al. Molecular characterization of 1-Cys and 2-Cys peroxiredoxins from the bumblebee Bombus ignitus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010, 155(3): 272-280
  22. Hu Z. et al. Molecular characterization of a phospholipid hydroperoxide glutathione peroxidase from the bumblebee Bombus ignitus. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010, 155(1): 54-61
  23. Xin Y., Choo Y.M., Hu Z., et al. Molecular cloning and characterization of a venom phospholipase A(2) from the bumblebee Bombus ignitus. Comp Biochem Physiol B Biochem Mol Biol. 2009, 154(2): 195-202.
  24. Hu Z., & Sohn, H. D. (2009). Molecular Cloning and Characterization of a Lipocalin in the Bumblebee Bombus Ignitus. International Journal of Industrial Entomology, 19(2), 229-235.
  25. Hu Z., et al. Molecular Cloning and Characterization of a Muscle-Specific Lipase from the Bumblebee Bombus ignitus.International Journal of Industrial Entomology, 2008, 17(1): 143-151.
  26. Zhao Y., Yao Q., Tang Xu., Wang Q., Hu Z., et al. Cloning and homologic analysis of Tpn I gene in silkworm bombyx mori, African Journal of Biotechnology, 2007, 6(6): 672-676.
  27. Hu Z., et al. Cloning and Characterization of Bombyx mori PP-BP a Gene Induced by Viral Infection, Acta Genetica Sinica, 2006, 33(11): 975-983.
  28. Hu Z., Chen K., Gao L., Yao Q. RNA Interference to Prevent Bombyx mori Nuclear Polyhedrosis Virus Infection in Vivo, IJIE, 2006, 12(1):15-19.
  29. Yao Q., Gao L., Chen K., Hu Z. Detection of proliferation of Bombyx mori nucleopolyhedrovirus in its host by fluorescence quantitative PCR. Acta entomological sinica. 200548(6)871-875. In Chinese.
  30. Hu Z.Chen K, Wang L, Yao Q. Identification and characterization of Bombyx mori eIF5A gene through bioinformatics approaches. In Silico Biol. 2005;5(5-6):573‐580.
  31. Yao Q., Hu Z., Chen K. Cloning and Characterization of Ribosome-associated Membrane Protein 4 (RAMP4) gene in silkworm Bombyx mori, International Journal of Industrial Entomology, 2005, 10(2):125-129.

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Email: huzg_2000@126.com

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